All the more reason to support diversity in general in the PC gaming space, especially as we have that option (console owners do not have that luxury). This video was posted on Polygon a few weeks back which discusses the general idea:
As a primary store for purchasing games, I think GOG is currently the best choice, given that all of the other big options enforce DRM - Origin, Battle.net, UPlay, and Steam all require their clients to be running to play a game. The Microsoft Store and Mac App Store don't require this, but still restrict installing and updating with DRM, and do not support competing OSs. Humble Store is good for DRM-free indie games, but if you want to use a client for updating you're generally tied to Steam or one of the others.